A problem worth solving

Most medicines are not available in liquid form because over 50% of all drugs are insoluble, or only sparingly soluble, in water or any other pharmaceutically acceptable solvent.

To be administered as a liquid, an insoluble drug must first be suspended. However, suspended medicines undergo sedimentation on standing, leading to a risk of under or overdosing.

In addition, only relatively low concentrations of insoluble drugs can be suspended, without the liquid becoming unacceptably viscous. For these reasons, the use of oral suspensions have largely been confined to paediatric medicine, where only a fraction of the adult dose is required.

Attempts to solve the problem of dispersing pharmaceuticals in water have usually involved the use of thickeners (e.g. gums or polymers) to raise the viscosity of the liquid medium, or viscosifiers to make colloidal dispersions. However, such systems are difficult to handle and are often incapable of dispersing relatively coarse particles.

Over 50% of all drugs are insoluble or sparingly soluble


BioSuspensions has developed SpheruliTEK™ - a novel Structured Suspension System for oral applications - which relies on the rheological properties of the suspending medium to immobilise particles, irrespective of size.

The result is a uniquely robust, low viscosity system with excellent suspension properties, tasteless constituents, and ability to tolerate the presence of high levels of sugar, if desired, e.g. in oral preparations to mask any unpleasant taste of the suspended drug.

The technology also has the potential to be used in parenteral applications, the subject of ongoing research at BioSuspensions.

SpheruliTEK™ has excellent suspension properties and tasteless constituents